Research
Here are some of the papers published over the years!
Highlighted
All
2025
CK2 inhibition suppresses glial inflammation in the brain.
bioRxiv : the preprint server for biology
·
07 Aug 2025
·
pubmed:41030967
Evolution of Human Susceptibility to Alzheimer's Disease: A Review of Hypotheses and Comparative Evidence.
Evolutionary anthropology
·
01 Mar 2025
·
pubmed:39806778
2024
Modeling Alzheimer's disease using human cell derived brain organoids and 3D models.
Frontiers in neuroscience
·
01 Aug 2024
·
pubmed:39156632
Exploring mood disorders and treatment options using human stem cells.
Genetics and molecular biology
·
01 Jul 2024
·
pubmed:38954533
Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission.
Molecular psychiatry
·
04 May 2024
·
pubmed:38704507
2023
NGLY1 mutations cause protein aggregation in human neurons.
Cell reports
·
30 Nov 2023
·
pubmed:38039131
Network size affects the complexity of activity in human iPSC-derived neuronal populations.
bioRxiv : the preprint server for biology
·
02 Nov 2023
·
pubmed:37961249
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis.
Molecular psychiatry
·
29 Mar 2023
·
pubmed:36991131
2022
Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons.
NPJ Parkinson's disease
·
18 Oct 2022
·
pubmed:36258029
Human-specific regulation of neural maturation identified by cross-primate transcriptomics.
Current biology : CB
·
12 Oct 2022
·
pubmed:36228612
Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients.
NPJ Parkinson's disease
·
10 Aug 2022
·
pubmed:35948563
Brain aging, Alzheimer's disease, and the role of stem cells in primate comparative studies.
The Journal of comparative neurology
·
05 Aug 2022
·
pubmed:35929189
Methods for culturing adult CNS neurons reveal a CNS conditioning effect.
Cell reports methods
·
18 Jul 2022
·
pubmed:35880023
Generation of inflammation-responsive astrocytes from glial progenitors derived from human pluripotent stem cells.
STAR protocols
·
17 Mar 2022
·
pubmed:35313707
Reaching into the toolbox: Stem cell models to study neuropsychiatric disorders.
Stem cell reports
·
20 Jan 2022
·
pubmed:35063127
2021
Unraveling Human Brain Development and Evolution Using Organoid Models.
Frontiers in cell and developmental biology
·
07 Oct 2021
·
pubmed:34692694
Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes.
Stem cell reports
·
04 Mar 2021
·
pubmed:33667413
Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients.
Molecular psychiatry
·
04 Jan 2021
·
pubmed:33398088
2020
Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis.
Molecular psychiatry
·
24 Aug 2020
·
pubmed:32839513
IGF-1 treatment causes unique transcriptional response in neurons from individuals with idiopathic autism.
Molecular autism
·
26 Jun 2020
·
pubmed:32591005
Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism.
Proceedings of the National Academy of Sciences of the United States of America
·
20 Apr 2020
·
pubmed:32312822
Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids.
Cell reports. Medicine
·
25 Mar 2020
·
pubmed:33205055
Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.
Proceedings of the National Academy of Sciences of the United States of America
·
10 Feb 2020
·
pubmed:32041882
A Physiological Instability Displayed in Hippocampal Neurons Derived From Lithium-Nonresponsive Bipolar Disorder Patients.
Biological psychiatry
·
04 Feb 2020
·
pubmed:32278494
Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability.
Cell stem cell
·
30 Jan 2020
·
pubmed:32004479
Modeling Inflammation on Neurodevelopmental Disorders Using Pluripotent Stem Cells.
Advances in neurobiology
·
01 Jan 2020
·
pubmed:32578148
2019
Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar Disorder.
Biological psychiatry
·
01 Oct 2019
·
pubmed:31732108
Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder.
Stem cell reports
·
29 Aug 2019
·
pubmed:31474529
An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack K
The Journal of neuroscience : the official journal of the Society for Neuroscience
·
26 Jul 2019
·
pubmed:31350261
Prediction of Response to Drug Therapy in Psychiatric Disorders.
Focus (American Psychiatric Publishing)
·
16 Jul 2019
·
pubmed:32015721
Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons.
Molecular psychiatry
·
22 Mar 2019
·
pubmed:30903001
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells.
eLife
·
07 Feb 2019
·
pubmed:30730291
Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders.
Antioxidants & redox signaling
·
01 Feb 2019
·
pubmed:30585734
Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons.
Molecular psychiatry
·
30 Jan 2019
·
pubmed:30700803
Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.
Nature neuroscience
·
07 Jan 2019
·
pubmed:30617258
2018
Modeling Inflammation in Autism Spectrum Disorders Using Stem Cells.
Frontiers in pediatrics
·
12 Dec 2018
·
pubmed:30619789
Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.
Cell stem cell
·
03 May 2018
·
pubmed:29727680
Prediction of response to drug therapy in psychiatric disorders.
Open biology
·
01 May 2018
·
pubmed:29794033
Characterization of calcium signals in human induced pluripotent stem cell-derived dentate gyrus neuronal progenitors and mature neurons, stably expressing an advanced calcium indicator protein.
Molecular and cellular neurosciences
·
06 Feb 2018
·
pubmed:29425968
Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward.
Genome medicine
·
04 Jan 2018
·
pubmed:29301565
2017
Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons.
Cell and tissue research
·
15 Aug 2017
·
pubmed:28812143
Examining non-LTR retrotransposons in the context of the evolving primate brain.
BMC biology
·
11 Aug 2017
·
pubmed:28800766
Intact piRNA pathway prevents L1 mobilization in male meiosis.
Proceedings of the National Academy of Sciences of the United States of America
·
19 Jun 2017
·
pubmed:28630288
Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells.
Stem cell reports
·
06 Jun 2017
·
pubmed:28591655
Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin.
Genes & development
·
15 Apr 2017
·
pubmed:28512238
Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.
Molecular psychiatry
·
28 Feb 2017
·
pubmed:28242870
Conserved expression of transposon-derived non-coding transcripts in primate stem cells.
BMC genomics
·
28 Feb 2017
·
pubmed:28245871
Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges.
Frontiers in cellular neuroscience
·
14 Feb 2017
·
pubmed:28261061
2016
Generating human serotonergic neurons in vitro: Methodological advances.
BioEssays : news and reviews in molecular, cellular and developmental biology
·
22 Sep 2016
·
pubmed:27716980
A human neurodevelopmental model for Williams syndrome.
Nature
·
10 Aug 2016
·
pubmed:27509850
Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility.
Nature
·
03 Aug 2016
·
pubmed:27487209
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.
Molecular psychiatry
·
05 Jul 2016
·
pubmed:27378147
Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience.
Nature reviews. Neuroscience
·
19 May 2016
·
pubmed:27194476
Evolution of a transcriptional regulator from a transmembrane nucleoporin.
Genes & development
·
19 May 2016
·
pubmed:27198230
2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.
Cell stem cell
·
31 Mar 2016
·
pubmed:27049876
KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome.
Proceedings of the National Academy of Sciences of the United States of America
·
05 Jan 2016
·
pubmed:26733678
The different moods of human serotonergic neurons.
Molecular psychiatry
·
01 Jan 2016
·
pubmed:26678308
2015
Synaptic activity: An emerging player in schizophrenia.
Brain research
·
23 Dec 2015
·
pubmed:26723567
Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder.
Nature
·
25 Nov 2015
·
pubmed:26605530
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.
Stem cell reports
·
21 Nov 2015
·
pubmed:26610635
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder.
Nature
·
28 Oct 2015
·
pubmed:26524527
Generation of functional human serotonergic neurons from fibroblasts.
Molecular psychiatry
·
27 Oct 2015
·
pubmed:26503761
Primate-specific ORF0 contributes to retrotransposon-mediated diversity.
Cell
·
22 Oct 2015
·
pubmed:26496605
Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest.
Cell
·
10 Sep 2015
·
pubmed:26365491
2014
Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons.
Molecular psychiatry
·
11 Nov 2014
·
pubmed:25385366
Mobile DNA elements in the generation of diversity and complexity in the brain.
Nature reviews. Neuroscience
·
09 Jul 2014
·
pubmed:25005482
A quantitative framework to evaluate modeling of cortical development by neural stem cells.
Neuron
·
02 Jul 2014
·
pubmed:24991955
How to make a hippocampal dentate gyrus granule neuron.
Development (Cambridge, England)
·
01 Jun 2014
·
pubmed:24917496
Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease.
Human molecular genetics
·
12 May 2014
·
pubmed:24821704
Modeling hippocampal neurogenesis using human pluripotent stem cells.
Stem cell reports
·
27 Feb 2014
·
pubmed:24672753
Your brain under the microscope: the promise of stem cells.
Cerebrum : the Dana forum on brain science
·
01 Jan 2014
·
pubmed:25009691
2013
Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons.
Human molecular genetics
·
30 Dec 2013
·
pubmed:24381312
Differential L1 regulation in pluripotent stem cells of humans and apes.
Nature
·
23 Oct 2013
·
pubmed:24153179
Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells.
Biological psychiatry
·
14 Sep 2013
·
pubmed:24041506
Therapeutic translation of iPSCs for treating neurological disease.
Cell stem cell
·
06 Jun 2013
·
pubmed:23746977
<a
href="https://www.ncbi.nlm.nih.gov/pubmed/23740898"
class="citation-image"
aria-label="Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells"."
>
<img
src=""
alt="Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells"."
loading="lazy"
onerror="this.src = '/images/fallback.svg'; this.onerror = null;"
>
</a>
Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".
Science translational medicine
·
05 Jun 2013
·
pubmed:23740898
Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells.
Stem cell research
·
16 May 2013
·
pubmed:23759711
Dynamic association of NUP98 with the human genome.
PLoS genetics
·
28 Feb 2013
·
pubmed:23468646
2012
Induced pluripotent stem cells: the new patient?
Nature reviews. Molecular cell biology
·
04 Oct 2012
·
pubmed:23034453
The role of DNA repair in the pluripotency and differentiation of human stem cells.
Mutation research
·
23 Sep 2012
·
pubmed:23010441
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Science translational medicine
·
01 Aug 2012
·
pubmed:22855461
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.
Proceedings of the National Academy of Sciences of the United States of America
·
18 Jul 2012
·
pubmed:22814375
Modeling brain disease in a dish: really?
Cell stem cell
·
14 Jun 2012
·
pubmed:22704498
2011
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.
Proceedings of the National Academy of Sciences of the United States of America
·
09 Dec 2011
·
pubmed:22159035
Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.
Human molecular genetics
·
09 Aug 2011
·
pubmed:21828073
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.
Human molecular genetics
·
17 Jun 2011
·
pubmed:21685205
2010
L1 retrotransposition in neurons is modulated by MeCP2.
Nature
·
18 Nov 2010
·
pubmed:21085180
A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.
Cell
·
12 Nov 2010
·
pubmed:21074045
Epigenetic choreographers of neurogenesis in the adult mammalian brain.
Nature neuroscience
·
01 Nov 2010
·
pubmed:20975758
LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?
Trends in neurosciences
·
12 May 2010
·
pubmed:20471112
Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases.
Human molecular genetics
·
23 Apr 2010
·
pubmed:20418487
Mechanisms underlying inflammation in neurodegeneration.
Cell
·
19 Mar 2010
·
pubmed:20303880
2009
Environmental influence on L1 retrotransposons in the adult hippocampus.
Hippocampus
·
01 Oct 2009
·
pubmed:19771587
Transcriptional signature and memory retention of human-induced pluripotent stem cells.
PloS one
·
18 Sep 2009
·
pubmed:19763270
2008
Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.
Cell stem cell
·
04 Dec 2008
·
pubmed:19041781
Identification of XP complementation groups by recombinant adenovirus carrying DNA repair genes.
The Journal of investigative dermatology
·
14 Aug 2008
·
pubmed:18685619
Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells.
Human molecular genetics
·
15 Apr 2008
·
pubmed:18632700
2007
Exploring DNA damage responses in human cells with recombinant adenoviral vectors.
Human & experimental toxicology
·
01 Nov 2007
·
pubmed:18042584
The necessary junk: new functions for transposable elements.
Human molecular genetics
·
15 Oct 2007
·
pubmed:17911158
LINE-1 retrotransposition in human embryonic stem cells.
Human molecular genetics
·
27 Apr 2007
·
pubmed:17468180
2006
Functional lentiviral vectors for xeroderma pigmentosum gene therapy.
Journal of biotechnology
·
03 Jun 2006
·
pubmed:16857285
2005
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition.
Nature
·
16 Jun 2005
·
pubmed:15959507
Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus.
Cancer gene therapy
·
01 Apr 2005
·
pubmed:15650764
2004
Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice.
Proceedings of the National Academy of Sciences of the United States of America
·
14 Dec 2004
·
pubmed:15598745
2002
Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer.
Human gene therapy
·
10 Oct 2002
·
pubmed:12396616
Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance.
Carcinogenesis
·
01 Jun 2002
·
pubmed:12082027
An adenovirus vector containing the suicide gene thymidine kinase for a broad application in cancer gene therapy.
Memorias do Instituto Oswaldo Cruz
·
01 Jun 2002
·
pubmed:12118289